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Some patients become depressed or suicidal while taking interferon beta-1a. If you begin to feel depressed or suicidal, contact your doctor. Severe liver problems (eg, the need for a liver transplant) have happened with interferon beta-1a. Your risk of liver problems may be greater if you drink alcohol while you are using interferon beta-1a. Interferon beta-1a commonly causes flu-like symptoms. Talk to your doctor about whether you should take a nonprescription medicine for pain or fever reduction before or after taking interferon beta-1a. Do NOT use more than the recommended dose. If you use more than your prescribed dose, contact your doctor right away. Interferon beta-1a may lower the ability of your body to fight infection. Avoid contact with people who have colds or infections. Tell your doctor if you notice signs of infection like fever, sore throat, rash, or chills. Interferon beta-1a may reduce the number of clot-forming cells (platelets) in your blood. Avoid activities that may cause bruising or injury. Tell your doctor if you have unusual bruising or bleeding. Tell your doctor if you have dark, tarry, or bloody stools. Injection-site reactions happen often with interferon beta-1a. Sometimes, very bad injection-site reactions may happen. Check with your doctor if you have any injection-site reactions that continue or become bothersome. Call your doctor right away if you have any break in the skin, color changes (blue or black), swelling, or drainage of fluid at the injection site. Interferon beta-1a contains albumin, which comes from human blood. There is a very rare risk of getting a viral disease or a CNS disease called Creutzfeldt-Jakob disease from products with albumin. No cases of these problems have been found in patients who have used interferon beta-1a. Lab tests, including blood cell counts, liver function, and thyroid function, may be performed while you use interferon beta-1a. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments. PREGNANCY and BREAST-FEEDING: If you become pregnant or if you plan on getting pregnant, contact your doctor. You will need to discuss the benefits and risks of using interferon beta-1a while you are pregnant. It is not known if interferon beta-1a is found in breast milk. If you are or will be breast-feeding while you use interferon beta-1a, check with your doctor. Discuss any possible risks to your baby.

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